Garfunkel and Oates are an American comedy–folk duo from Los Angeles, California, consisting of actress–songwriters Riki Lindhome (Garfunkel) and Kate Micucci (Oates). The band name is derived from "two famous rock-and-roll second bananas", Art Garfunkel and John Oates.

The two met at the Upright Citizens Brigade Theatre in Los Angeles, where they were introduced to one another by comic Doug Benson. The duo was formed when they started working together to turn "Imaginary Larry", a short film made by Lindhome, into a musical. Lindhome is from Coudersport, Pennsylvania; Micucci is from Nazareth, Pennsylvania.

In February 2009, the Garfunkel and Oates song "Fuck You" (reworked as "Screw You") was featured in the Scrubs episode "My Lawyer's in Love", which featured Micucci in a supporting role.

On December 14, 2009, Garfunkel and Oates were on The Jay Leno Show to perform their song "Year End Letter". On The Tonight Show with Jay Leno, they performed "Pregnant Women Are Smug" on March 12, 2010, and "Self-Esteem" on May 18, 2010. In late October 2010, they performed "Weed Card" on The Tonight Show.

In 2010 they were featured on the track "These Girls", on Childish Gambino's album Culdesac.

In 2011, Garfunkel and Oates signed a deal with HBO for a pilot for their own show. Lindhome has described it as "Glee with dick jokes". HBO later decided not to go forward with the show. In August 2012, webisodes were posted to HBO's online service.

On October 7, 2011, they released a song for David Wain's web series Wainy Days titled "David Wain Is Sexy" and is available on the extras on the DVD of Wainy Days.

On June 8, 2012, Comedy Central featured an episode of The Half Hour with Garfunkel and Oates.

On June 25, 2013, the duo released their music video "The Loophole", a song about Christian girls retaining their virginity by performing anal sex, which is not specifically forbidden in the Bible.

On September 30, 2013, IFC network green-lit Garfunkel and Oates, an eight-episode half-hour show featuring the duo. The show premièred on August 7, 2014 and was cancelled on 3 March 2015.

In "The Romance Resonance," an episode of The Big Bang Theory, the character Howard played the song "If I Didn't Have You (Bernadette's Song)", written by Garfunkel and Oates, for his on-screen wife Bernadette.

In 2014, Garfunkel and Oates was listed on New Media Rockstars Top 100 Channels, ranked at #81.